Melanotan 1 is a synthetic 13-residue peptide built on the alpha-MSH framework, with norleucine at position 4 and D-phenylalanine at position 7. Its sequence is Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2, formula C78H111N21O19, reference weight about 1,646.8 g/mol, CAS 75921-69-6. It is a linear chain, unlike the cyclic Melanotan 2, which is a separate molecule with a much lower mass. Supplied as a 10 mg vial and intended for laboratory research only.
Ask for the analytical documentation of any lot.
HPLC is the method used to measure purity
Ask for the report for a specific lot through the contact page
Supplied for laboratory research use only
Mass spectrometry is the method used to confirm identity
Melanotan 1 is a synthetic melanocortin peptide analogue built on the structure of α-MSH. It is a linear chain of thirteen amino acids, with norleucine in place of methionine at position 4 and D-phenylalanine in place of phenylalanine at position 7. Veracue supplies it for laboratory research only.
Those two substitutions make the peptide far more resistant to enzymatic breakdown than native α-MSH, which degrades too quickly to study easily under controlled conditions. That stability is why it became a useful research tool.
| Product name | Melanotan 1 |
| Also written | Melanotan-1, Melanotan-I, MT-1, MT1 |
| Structural name | [Nle4, D-Phe7]-α-MSH |
| Peptide class | Synthetic melanocortin peptide; α-MSH analogue |
| Length | 13 residues, linear |
| Sequence | Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2 |
| Molecular formula | C78H111N21O19 |
| Reference molecular weight | Approximately 1,646.8 g/mol |
| CAS number | 75921-69-6 |
| Size offered | 10 mg vial |
| Research designation | Research Use Only |
These are reference values for the molecule. Salt or counterion form, net peptide content, purity, lot number and storage conditions are reported on each lot’s documentation and can be requested through the contact page.
Melanotan 1 is a linear tridecapeptide with an acetylated N-terminus and an amidated C-terminus, which places it in the peptide class rather than among small molecules. Its full structural name is [Nle4, D-Phe7]-α-MSH.
Record the reference identity first: Melanotan 1, the structural notation [Nle4, D-Phe7]-α-MSH, the full sequence and CAS 75921-69-6. Abbreviations such as MT-1 are fine as shorthand once that identity is established, but they are ambiguous on their own. Then record the supplier, lot number and any analytical documentation for the specific material used, as a separate entry.
Conventions vary. A source may report average or monoisotopic mass, and it may describe the free peptide or a salt form. When comparing figures, check which convention is in use before assuming two numbers disagree about identity.
The two names are often used as if they were interchangeable. They are different molecules that share a receptor-recognition motif, and the comparison here is scientific only.
| Attribute | Melanotan 1 | Melanotan 2 |
|---|---|---|
| Molecular class | Linear α-MSH analogue | Cyclic α-MSH analogue |
| Structure | Linear tridecapeptide | Cyclic heptapeptide (lactam-bridged) |
| Sequence | Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2 | Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2 |
| Approximate molecular weight | 1,646.8 g/mol | 1,024.2 g/mol |
| Relationship to α-MSH | Full-length analogue with Nle4 and D-Phe7 substitutions | Truncated, cyclised analogue keeping the His-D-Phe-Arg-Trp core |
| Receptor research context | Described in the literature as acting predominantly at MC1R | Described in the literature as active across several melanocortin receptor subtypes |
For record keeping, treat them as separate entities. Mass calculations, published findings and identity checks do not carry across from one to the other, and figures quoted for Melanotan 2 should not be applied to Melanotan 1.
The research interest centres on the melanocortin 1 receptor (MC1R), which responds to α-MSH and its analogues. In receptor-expressing cell systems, activation of the receptor raises intracellular cyclic AMP. A stable analogue like Melanotan 1 gives researchers a practical tool for probing that signalling under controlled laboratory conditions.
| Evidence type | What it tells you | What it does not prove |
|---|---|---|
| Molecular / biochemical | Structural identity and chemical behaviour | Any biological outcome |
| Receptor / cellular | Activity in a defined laboratory system | Behaviour in an intact organism |
| Certificate of analysis | Lot-specific analytical results by the stated method | Biological activity or fitness for any use |
Mechanistic rationale explains why the peptide is studied. It does not establish an outcome or any product-specific effect.
It reports molecular reference information and general research context. It cannot establish what is in a particular vial. Veracue does not provide dosing, administration or usage guidance of any kind.
A certificate of analysis links a set of analytical results to a specific lot. Confirm that the product name and lot number match the material in hand, not a representative batch. Then check how identity was established, what the assay or purity result actually measures, which method and date were used, and which laboratory did the testing.
| COA field | What to verify |
|---|---|
| Product name | Matches the material |
| Lot number | Matches the supplied lot |
| Identity | Shows how identity was evaluated |
| Assay / purity | Defines exactly what was measured |
| Analytical method | Identifies the method |
| Analysis date | Establishes the testing date |
| Laboratory | Identifies the testing source |
| Specification | Shows the acceptance criterion where applicable |
The formula, the reference weight of about 1,646.8 g/mol and the sequence describe the intended molecule. They are not a measurement of any particular vial. A supplier’s analytical result is a separate claim, tied to one lot and one method, so the two should be recorded and compared side by side rather than treated as the same thing.
Salt or counterion form, net peptide content, purity result, analytical method and storage conditions are supplier-specific. Confirm them through the documentation for the lot you hold. Conditions for another Veracue peptide should not be transferred to this material.
The certificate page explains how to see lot documentation.
Ask the Veracue team for the documentation that belongs to a specific lot, or browse the certificate library.
Melanotan 1 supplied by Veracue is for laboratory research purposes only. It is not a drug, supplement, cosmetic or food, and it is not intended for human or veterinary use, ingestion, injection or any form of administration. This page provides no dosing, administration or usage guidance. See the Medical Disclaimer and the Terms and Conditions for sitewide policies, or the Help and FAQ page for general questions.
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