Snap8 is a synthetic octapeptide with the sequence Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2, acetylated at the N-terminus and amidated at the C-terminus. Its reference record gives the formula C41H70N16O16S, a molecular weight of 1075.2 g/mol and CAS 868844-74-0. It is modeled on a short stretch of SNAP-25 and is easily confused with Argireline, a shorter six-residue peptide that lacks the final alanine and aspartic acid. Both the 10 mg and 20 mg vials are supplied strictly for laboratory research.
Ask for the analytical documentation of any lot.
HPLC is the method used to measure purity
Ask for the report for a specific lot through the contact page
Supplied for laboratory research use only
Mass spectrometry is the method used to confirm identity
Snap8 is a synthetic octapeptide, Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2, modeled on a short sequence from SNAP-25, a protein that forms part of the SNARE membrane-fusion complex. It is built in a laboratory, not isolated from a natural source. Veracue supplies it for laboratory research only.
Snap8 is not a naturally occurring SNAP-25 fragment. It is a laboratory-made peptide corresponding to part of that sequence, which is why it is used as a reference material in SNARE-related assay work.
| Product name | Snap8 (also written Snap-8 or SNAP-8) |
| Sequence | Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2 (Ac-EEMQRRAD-NH2) |
| Length | 8 amino acid residues, N-terminally acetylated and C-terminally amidated |
| Molecular formula | C41H70N16O16S |
| Molecular weight | 1075.2 g/mol |
| CAS Registry Number | 868844-74-0 |
| PubChem CID | 76283482 |
| Available sizes | 10 mg and 20 mg vials |
| Research designation | Research Use Only |
Formula, weight and CID are from the PubChem record linked to CAS 868844-74-0. That record describes the peptide as a reference structure and is not a statement about the form Veracue supplies. Some third-party listings describe an acetate salt. Salt or counterion form, purity, lot results and storage conditions are reported on each lot’s documentation and can be requested through the contact page.
Read left to right, the sequence is two glutamic acid residues, a methionine, a glutamine, two arginines, an alanine and an aspartic acid. The Ac- at the front means the N-terminus carries an acetyl group in place of a free amine, and the -NH2 at the end means the C-terminus is amidated instead of a free carboxylic acid.
Both end modifications are common in synthetic peptide chemistry and tend to improve a peptide’s stability against enzymes that attack from either end. A different length, order or terminal capping describes a different compound.
PubChem holds more than one deposited record for this peptide, and the structure or formula shown differs slightly between them. The record linked to CAS 868844-74-0 (CID 76283482) is used here because its sequence and formula match the conventional Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2 structure. The exact monoisotopic mass is not published in that record, so none is stated here.
Reference identity comes from chemical records, while lot identity comes from lot-specific analytical documentation. Those are two different things, and a name printed on a vial does not replace the second.
No. Argireline is a related, shorter six-residue peptide, Ac-Glu-Glu-Met-Gln-Arg-Arg-NH2. Snap8 extends that sequence by two residues, alanine and aspartic acid, giving a distinct eight-residue compound with its own formula, weight and CAS registration. The two share a design lineage but should not be treated as interchangeable. Naming conventions for this class of peptide also vary between databases and suppliers, so a name alone should not be taken as confirming identity.
| Attribute | Snap8 | GHK-Cu |
|---|---|---|
| Molecular identity | Synthetic linear octapeptide, Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2 (CAS 868844-74-0) | Copper(II) complex of the tripeptide Gly-His-Lys |
| Structural class | Acetylated, amidated 8-residue synthetic peptide | Metal-coordinated tripeptide complex |
| Chemical identity | 8 amino acids; C41H70N16O16S; 1075.2 g/mol | 3 amino acids plus a coordinated copper(II) ion; distinct formula and weight |
| Research context | Designed around a proposed SNARE-complex, SNAP-25-related interaction | Studied in a separate literature on copper-peptide signaling |
The two are structurally and mechanistically unrelated, and the table does not rank them.
SNAP-25 (synaptosomal-associated protein of 25 kDa) is a well-characterized full-length protein. Together with syntaxin-1 and VAMP/synaptobrevin it forms the core SNARE complex behind vesicle docking and membrane fusion. Snap8 corresponds to a short stretch of the SNAP-25 sequence, near its N-terminal region.
The design premise is that a free-standing peptide of this kind might occupy a position within SNARE assembly and interfere with its normal formation. That is a structural and competitive hypothesis. Snap8 does not enzymatically cleave SNAP-25, does not replace it, and is not shown to inhibit it directly.
SNAP-25 and the SNARE complex are well characterized in cell biology generally. What is less established is an extensive, independent body of biochemical work testing Snap8 itself against that system. Treat the SNARE-interference idea as the working hypothesis the peptide was designed around, not as a demonstrated mechanism in every laboratory model.
Veracue does not provide dosing, administration or usage guidance of any kind.
A certificate of analysis documents one lot, so read it as a set of linked facts. Certificates vary between laboratories and testing programs, so treat this as what a COA may include rather than a fixed checklist.
| COA item | What it helps establish |
|---|---|
| Lot or batch identifier | Which production run the results describe. It should match the vial. |
| Material name and reference sequence | That the record ties the material to Ac-EEMQRRAD-NH2. |
| Identity confirmation method | How the sequence or identity was confirmed. |
| Analytical method | For example RP-HPLC or ESI-MS. |
| HPLC chromatogram or purity percentage | The reported chromatographic purity and the trace behind it. |
| Mass spectrometry identity data | Whether the observed mass fits the theoretical sequence mass. |
| Testing date and laboratory | How recent the result is and who performed the analysis. |
| Chemical form or counterion | Free peptide, acetate salt or another form, where relevant. |
Every field above depends on the lot’s own documentation, and Veracue confirms a field only when the lot certificate reports it. Check that the pieces agree with each other. The certificate page explains how to request lot documentation.
Molecular weight is not the same figure as the mass-to-charge ratio (m/z) on a mass spectrum. Peptides often ionize into more than one charge state during electrospray ionization, and salts or adducts can shift the observed ion mass away from the calculated neutral weight of 1075.2 g/mol.
Mass spectrometry is mainly used to confirm identity, meaning the observed mass matches the theoretical sequence mass within an expected tolerance. Chromatography such as HPLC is what typically establishes purity and composition. No single expected peak is asserted here, because it depends on the instrument, the ionization method and the chemical form used for a given lot.
A name on a label does not establish identity. Start with the documented sequence Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2, CAS 868844-74-0 and the formula C41H70N16O16S. Then cross-check them against that specific lot’s own mass spectrometry and HPLC results.
A product page can give general reference information such as sequence, formula, weight and CAS. It cannot establish the purity, identity or composition of an individual lot. Treat the lot’s own COA as the operative record for that lot.
Ask the Veracue team about available documentation for a specific lot, or review the certificate library.
Snap8 is supplied for laboratory research, scientific investigation and analytical characterization only. It is not intended for human or veterinary use, and it is not a drug, dietary supplement, cosmetic or food. This page provides no dosing, administration or usage guidance of any kind. See the Medical Disclaimer and the Terms and Conditions for sitewide policies.
RESEARCH PEPTIDE
AHK-Cu has a different molecular weight for each form, from 354.41 to 452.40 g/mol, so check the form on your COA. 50 and 100 mg, research use only.
RESEARCH PEPTIDE
GHK-Cu is a copper complex, not the free GHK peptide, so the form on your COA matters (CAS 89030-95-5). 50 mg and 100 mg vials, research use only.
