Semax/Selank is a research blend of two separate synthetic heptapeptides. Semax is Met-Glu-His-Phe-Pro-Gly-Pro (C37H51N9O10S, average mass 813.93, CAS 80714-61-0) and Selank is Thr-Lys-Pro-Arg-Pro-Gly-Pro (C33H57N11O9, average mass 751.89, CAS 129954-34-3). Both end in a Pro-Gly-Pro tail, which is why the two names are so easily mixed up. The vial holds 10 mg of each peptide and is supplied for laboratory research use only.
Ask for the analytical documentation of any lot.
HPLC is the method used to measure purity
Ask for the report for a specific lot through the contact page
Supplied for laboratory research use only
Mass spectrometry is the method used to confirm identity
Semax/Selank is a blend of two distinct synthetic heptapeptides. Semax (Met-Glu-His-Phe-Pro-Gly-Pro) is derived from an ACTH fragment, and Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro) is derived from the tuftsin sequence. Both carry a Pro-Gly-Pro tail. Veracue supplies the blend for laboratory research only.
The two names turn up in the same searches, and terms like “semax and selank” can suggest a single molecule. They are two molecules with different first four residues, different parent sequences and different masses, so a finding for one should not be carried over to the other.
| Product name | Semax/Selank |
| Components | Semax and Selank, two separate synthetic heptapeptides |
| Semax sequence | Met-Glu-His-Phe-Pro-Gly-Pro (MEHFPGP) |
| Selank sequence | Thr-Lys-Pro-Arg-Pro-Gly-Pro (TKPRPGP) |
| Average molecular weight (reference) | Semax 813.93 g/mol; Selank 751.89 g/mol |
| CAS Registry Numbers | Semax 80714-61-0; Selank 129954-34-3 |
| Size offered | 10 mg of Semax and 10 mg of Selank |
| Research designation | Research Use Only |
Formulas and masses are reference values for the free-acid form of each peptide. They describe the molecules, not any particular vial. Purity, identity, chemical form and lot results are reported on each lot’s documentation and can be requested through the contact page.
| Attribute | Semax | Selank |
|---|---|---|
| Alternate names | ACTH(4-7)-Pro-Gly-Pro; MEHFPGP | Selanc; TKPRPGP |
| Sequence | Met-Glu-His-Phe-Pro-Gly-Pro | Thr-Lys-Pro-Arg-Pro-Gly-Pro |
| Length | 7 amino acids | 7 amino acids |
| Molecular formula | C37H51N9O10S | C33H57N11O9 |
| Average molecular weight | 813.93 g/mol | 751.89 g/mol |
| Monoisotopic mass (calculated) | 813.348 Da | 751.434 Da |
| CAS Registry Number | 80714-61-0 | 129954-34-3 |
| PubChem CID | 9811102 | 11765600 |
| Derived from | ACTH(4-7) fragment plus Pro-Gly-Pro | Tuftsin (Thr-Lys-Pro-Arg) plus Pro-Gly-Pro |
The two peptides are the same length and share the Pro-Gly-Pro ending, so length will not tell them apart. Composition will: Semax contains sulfur through its methionine and Selank does not. The table does not rank either peptide.
“ACTH-derived” describes ancestry, not identity. ACTH is a 39-residue hormone, and ACTH(4-10) is the seven-residue fragment Met-Glu-His-Phe-Arg-Trp-Gly. Semax keeps the first four residues of that fragment and swaps the last three for Pro-Gly-Pro. Semax is not ACTH and it is not ACTH(4-10).
Tuftsin is a naturally occurring tetrapeptide, Thr-Lys-Pro-Arg. Selank is that sequence extended with Pro-Gly-Pro, a change described as improving metabolic stability. It is an analog, related in origin and different as a molecule, so tuftsin data should not be assumed for Selank.
Semax acetate (C39H55N9O12S, about 874.0 g/mol) is a separate chemical form from the free peptide, and supplier naming is not always consistent about which one is meant. Salt forms of Selank, such as acetate, are likewise separate chemical forms. Names like “N-acetyl Semax” describe chemically modified compounds and are not covered here.
In an in vitro enzyme study, both peptides inhibited enkephalin-degrading enzymes, with reported IC50 values of about 10 µM for Semax and 20 µM for Selank. Labeled Semax has been shown to bind rat basal forebrain membranes, and it stimulated BDNF synthesis in cultured rat astrocytes. In rat hippocampal work, Semax was reported to raise BDNF protein and trkB signaling.
For Selank, radioligand experiments reported positive allosteric modulation of GABA binding, and rat cortex studies found broad shifts in gene expression related to neurotransmission. Selank has also been reported to affect BDNF expression in rat hippocampus.
Most of this work comes from cell and rodent systems and from a small number of research groups, and routes, timing and models differ from paper to paper, so the results do not add up to one neat picture. Semax work leans toward neurotrophin signaling, while Selank work leans toward GABA-related signaling and gene expression. Only one in vitro study tested both peptides, so the two literatures cannot be lined up head to head.
Nothing in the published work reviewed here demonstrates a combined or synergistic effect between the two peptides. A combination would be its own experimental question with its own design and controls. The mechanisms of both peptides are still being worked out, and observations in a tissue or cell system are not the same as an established mechanism.
A certificate of analysis documents one lot, not the compounds in general. Depending on the laboratory, it may include the items below. For a blend, look for each item to cover both peptides, because a single result for one component does not describe the other.
| COA item | What it helps establish |
|---|---|
| Lot number | Which production run the results describe. It should match the vial. |
| Peptide names, sequences or formulas | Whether the record names both Semax and Selank and ties each to its own sequence. |
| Analytical method and conditions | The method and detection conditions behind the results. |
| HPLC chromatogram and purity result | How much of the material elutes as the target peak or peaks. |
| Mass spectrometry identity result | Whether detected masses fit the expected molecules. |
| Test date and laboratory information | Who performed the analysis and how recent it is. |
| Chemical form | Free peptide, acetate or another salt, and sometimes counterion or water content. |
Check that the lot on the certificate matches your vial and that the named peptides and sequences match what you expect. Any field above depends on the lot’s own documentation, and the certificate page explains how to request lot documentation.
Because the vial holds two peptides, a full identity check has two parts. Semax should be matched to Met-Glu-His-Phe-Pro-Gly-Pro, C37H51N9O10S, average mass 813.93, and Selank to Thr-Lys-Pro-Arg-Pro-Gly-Pro, C33H57N11O9, average mass 751.89. A record that confirms only one of the two leaves the other unverified.
| Value | Semax | Selank |
|---|---|---|
| Calculated monoisotopic mass | 813.348 Da | 751.434 Da |
| Average molecular weight | 813.93 g/mol | 751.89 g/mol |
HPLC shows how much of the material elutes as the target peak, but it cannot say the peak is the right molecule. Mass spectrometry shows whether a detected mass fits the expected molecule, but it does not quantify purity. A COA that ties both results to a lot number matching your vial gives firmer assurance than one that does not.
A mass spectrometer detects ions, not vials. A peptide can carry one or more charges, so one molecule can show up at several m/z values, and observed signals will not match the molecular weight on a data sheet. Adducts, counterions and chemical modifications can shift or add signals, and methionine-containing peptides such as Semax can oxidize. Interpretation belongs to the analytical record and its method conditions, which is why no expected peak values are listed here.
Molecular weight is an average across natural isotopes and is the number on most data sheets. Monoisotopic mass uses the single most abundant isotope of each element, which is closer to what a high-resolution instrument resolves. m/z is mass divided by charge, for an ion rather than the neutral molecule. An expected mass describes the molecule. It does not show that a given vial contains it.
Ask the Veracue team about available documentation for a specific lot, or review the certificate library. Molecular facts belong to the molecule, while analytical facts belong to the lot, so ask for the documentation for your lot before treating any figure as verified.
Semax and Selank are offered for laboratory research and analytical use only. They are not intended for human or veterinary use, for ingestion, injection or any form of administration, or to diagnose, treat, cure or prevent any disease. Statements on this page have not been evaluated by the U.S. Food and Drug Administration. This page provides no dosing, administration or usage guidance of any kind. See the Medical Disclaimer and the Terms and Conditions for sitewide policies.
RESEARCH PEPTIDE
Selank (TKPRPGP) is a seven-residue tuftsin analog of about 751 g/mol. Compare it with Semax and read the COA. 10 mg vial available, research use only.
RESEARCH PEPTIDE
DSIP is a nine-residue peptide, WAGGDASGE (CAS 62568-57-4). Check the mass and the lot COA. Sold as a 10 mg vial for research use only.
RESEARCH PEPTIDE
Semax (MEHFPGP) is a seven-residue peptide: ACTH(4-7) plus a Pro-Gly-Pro tail (CAS 80714-61-0). See mass and COA tips. 10 and 30 mg, research use only.
