# Kisspeptin Spray

> Research use only. Not for human or veterinary use. Supplied by Veracue Labs.

- Page: https://veracuelabs.com/product/kisspeptin-spray
- Category: Nasal Sprays
- Sizes and prices in USD: 10 mg at $104.49
- Certificate of analysis: none posted on the page. Request one for a specific lot at https://veracuelabs.com/contact-us.
- Prices are a snapshot from 2026-10-17. The product page shows the current price.

## Overview

Kisspeptin Spray is a spray-dispensed bottle of kisspeptin-10, the shortest natural kisspeptin: a linear decapeptide, Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe, with an amidated C-terminus. Reference values for the free peptide are formula C63H83N17O14, average mass 1302.45 g/mol and CAS 374675-21-5. Every natural kisspeptin ends in this same ten-residue core, so a label reading only "kisspeptin" leaves the chain length open, while a mass near 1302 rules out the 54-residue form at about 5857.

## Product Details

### Kisspeptin Spray Specifications

Product name: Kisspeptin Spray
Compound: Kisspeptin-10, synthetic
Also written as: Metastin (45-54), KISS-1 (112-121), KP-10
Format: Spray-dispensed bottle
Sprays per bottle: 45 sprays per bottle
Size offered: 10 mg
Chain: 10 amino acids, linear, C-terminal amide
Sequence (three-letter code): Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2
Sequence (one-letter code): YNWNSFGLRF-NH2
Free-peptide formula: C63H83N17O14
Average mass: 1302.45 g/mol
Monoisotopic mass (calculated from the formula): About 1301.63 Da
CAS Registry Number: 374675-21-5
PubChem CID: 25240297
Research designation: Research Use Only

The formula, both masses and the CAS number above are reference values for the free peptide and were not measured on any lot. Anything specific to one lot, such as chemical form, fill volume, concentration, carrier or purity, sits in that lot’s own documentation, and documentation can be requested through the contact page.

### The Peptide in the Bottle

The bottle holds kisspeptin-10, the C-terminal ten-residue piece of the longer kisspeptin chain. Read from the N-terminus it is tyrosine, asparagine, tryptophan, asparagine, serine, phenylalanine, glycine, leucine, arginine and phenylalanine, with the last residue amidated. It is one defined molecule, offered in a 10 mg size with 45 sprays per bottle.

Metastin (45-54), KISS-1 (112-121) and KP-10 all name this same ten-residue peptide. The first numbering counts from the start of kisspeptin-54 and the second from the start of the KISS1 gene product, which is why the ranges differ.

### What the Name “Kisspeptin” Covers

Kisspeptin is a family name rather than a single compound. A precursor encoded by the KISS1 gene is cut into peptides of 54, 14, 13 and 10 residues, and the shorter ones sit inside the longer, sharing one C-terminal end. Their receptor is KISS1R, also known as GPR54.

A bare “kisspeptin” label therefore does not fix the chain length, whereas a sequence, formula and mass do.

### What This Listing Is Not

- Not kisspeptin-54, a much longer chain with its own formula, mass and CAS number.
- Not a gene or a receptor: KISS1 is the gene and KISS1R the receptor protein, and neither is a peptide reagent.
- Not described by its spray count, which is a packaging figure only.
- Not a pharmaceutical, nutritional or cosmetic item.
- Not for use in people or animals.

## Research Focus & Mechanism Overview

### Sequence Features Worth Knowing

### Which residues stand out?

Counting from the N-terminus: tyrosine at 1, asparagine at 2, tryptophan at 3, asparagine at 4, serine at 5, phenylalanine at 6, glycine at 7, leucine at 8, arginine at 9 and a C-terminal phenylalanine amide at 10. There is no cysteine, so no disulfide bond can form, and no methionine, lysine, histidine or proline. Arginine 9 is the only basic side chain, and the free N-terminal amine is the only other group that readily takes a proton.

Two spots in the chain tend to show up in mass data. Tryptophan 3 can pick up oxygen, which adds about 16 Da. The asparagines at 2 and 4 can lose their amide nitrogen to become aspartate or isoaspartate, which adds just under 1 Da. Tryptophan and tyrosine also absorb near 280 nm, so ultraviolet detection at that wavelength gives a second view of a sample beside the peptide-bond absorbance read at shorter wavelengths.

### What does the C-terminal amide change?

The last phenylalanine ends in an amide group, not a carboxylic acid. A free-acid version of the same ten residues would be a distinct species, heavier by about 0.98 Da, and that gap is easy to overlook when a record leaves out the “-NH2”.

### Kisspeptin-10 Beside Its Longer Relatives

Kisspeptin-54, covering KISS1 residues 68 to 121, is the longest of the four natural forms and contains all of kisspeptin-10 at its C-terminal end. Its reference values are formula C258H401N79O78, average mass 5857.43 g/mol, CAS 374683-24-6 and PubChem CID 71306396, which puts it about 4555 Da above kisspeptin-10.

Kisspeptin-14 and kisspeptin-13 fall between the two in length. Every residue in a peptide chain adds at least 57 Da, so even kisspeptin-13, three residues longer than kisspeptin-10, would read above 1470 Da. A mass near 1302 therefore points to the ten-residue peptide, and sequence evidence is still needed to confirm residue order.

### Receptor Background at the Assay Level

KISS1R is a G protein-coupled receptor that signals through Gq/11. Engagement activates phospholipase C, which produces inositol trisphosphate and diacylglycerol, and the downstream result is a rise in intracellular calcium together with protein kinase C activation. Calcium mobilization and inositol phosphate accumulation are accordingly common readouts in cell-based work.

Published work reports that kisspeptin-10 activates KISS1R at or near the potency of the longer forms, which is one reason the short peptide is a practical reference ligand. Laboratories use it for receptor pharmacology, for comparisons with the longer forms and for signal-transduction readouts.

What a given assay shows applies to that system and that kisspeptin form only. Veracue offers no dosing, administration or usage guidance of any kind.

### Recording a Spray Bottle in the Lab Notebook

A methods section reads best when the molecule is named by sequence or CAS number and the physical item is identified separately, by lot number and bottle label. For this listing the useful entries are the peptide (kisspeptin-10, YNWNSFGLRF-NH2), the 10 mg size, the 45-spray count, the lot number and the date received. The spray count is a packaging figure only.

## Quality & Purity Standards

### What a Mass Spectrum of Kisspeptin-10 Should Show

At 1.3 kDa this peptide is small enough that a singly charged ion is often seen beside the doubly charged one. The values below were calculated from the free-peptide formula.

Ion: Average-mass m/z: Monoisotopic m/z

[M+H]+: 1303.46: 1302.64
[M+2H]2+: 652.23: 651.82

To read a peak list, turn each m/z into a neutral mass by multiplying by the charge and taking off one proton mass per charge, then check that the results agree. Note whether a report is on an average or a monoisotopic basis, since the two differ by roughly 0.8 Da at this size.

### Interpreting What You See

Observation: Reasonable reading

Every charge state converts to one neutral mass near 1302.45 (average basis): The expected free peptide, as a single species
A minor signal about 16 Da higher: Oxidation, with tryptophan 3 the usual suspect
A signal just under 1 Da higher: Isotope pattern, deamidation at asparagine 2 or 4, or a free-acid C-terminus; fragment data helps separate them
A dominant mass near 5857: Kisspeptin-54 rather than kisspeptin-10
A main mass far from both 1302 and 5857: A different chain length, a modified peptide or a different chemical form

### Lot Documentation

A lot document speaks only for the lot it names, so begin by matching its lot number to the label on the bottle. Then look for the compound name and chemical form, an HPLC trace with its method, an observed and an expected mass, the test date and the laboratory that ran the work. Documentation can be requested through the contact page.

Fill volume and concentration, where a lot document reports them, are lot-specific details and are not implied by the spray count.

### Verification Questions

### Does a clean HPLC trace identify the peptide?

No. A chromatogram reports how much of the detected signal sits in one peak, not what that peak is. A well-resolved trace of a different kisspeptin form would look just as clean, so it needs a mass result from the same lot beside it.

### Why are the formula and mass quoted for the free peptide?

Synthetic peptides are commonly handled as salts, and the counterion adds weight that the free-peptide formula leaves out. A lot document that states its form, and whether its figures count the whole material or only the peptide, lets those numbers be compared with the reference values listed here.

### Can mass alone confirm the sequence?

It narrows the options sharply, but two peptides built from the same residues in a different order weigh the same. Residue order is confirmed with fragment-ion data such as MS/MS.

### Questions about a lot?

Write to the Veracue team through the contact page about documentation, or browse the full research catalog.

## Compliance Notice

### Research Use Only Notice

Kisspeptin Spray is a laboratory reagent sold for research and analytical work only. It is not a pharmaceutical, nutritional or cosmetic product, and it is not intended for people or animals in any way. Veracue provides no dosing, administration or usage guidance of any kind. Buyers are qualified researchers or institutions who remain responsible for lawful handling. Sitewide terms are set out in the Medical Disclaimer and the Terms and Conditions.

## Questions and answers

### What peptide does Kisspeptin Spray contain?

Kisspeptin-10, a synthetic linear decapeptide with the sequence YNWNSFGLRF-NH2 and an amidated C-terminus. Its reference formula is C63H83N17O14 and its CAS number is 374675-21-5.

### How many sprays come in a bottle, and what size is offered?

Each bottle holds 45 sprays, and the size offered is 10 mg. The spray count is a packaging figure only.

### Why does the word “kisspeptin” alone not identify a compound?

It names a family of peptides of 54, 14, 13 and 10 residues that share one C-terminal end. Only the sequence, formula or mass shows which length a product is.

### How far apart are kisspeptin-10 and kisspeptin-54 by mass?

About 4555 Da: kisspeptin-10 is 1302.45 g/mol and kisspeptin-54 is 5857.43 g/mol. A mass spectrum separates them at a glance.

### Which residues are the usual suspects when a signal sits above the expected mass?

Tryptophan 3 can oxidize, adding about 16 Da, and the asparagines at positions 2 and 4 can deamidate, adding just under 1 Da. A free-acid C-terminus also reads about 0.98 Da high.

### What ions should a mass spectrometer show for this peptide?

Calculated average-mass values are about 1303.46 for the singly charged ion and 652.23 for the doubly charged ion. Monoisotopic values are about 1302.64 and 651.82.

### What does the C-terminal amide mean for identity checks?

The last phenylalanine is an amide, not a carboxylic acid, and the free-acid form would be a different species about 0.98 Da heavier. A record that omits the “-NH2” can slip through a quick mass comparison.

### Why are the formula and mass given for the free peptide?

They are reference values for the peptide itself, not lot measurements. A salt form carries extra counterion weight, so a lot document should state which form its figures describe.

### Which receptor do kisspeptins act on in assays?

KISS1R, also called GPR54, a Gq/11-coupled receptor. Engagement activates phospholipase C and raises intracellular calcium, so calcium and inositol phosphate readouts are common.

### Is the kisspeptin-10 sequence part of the longer kisspeptins?

Yes. All four natural forms end in the same ten-residue sequence, and kisspeptin-10 is that core on its own.

### Does a clean HPLC trace prove the peptide is kisspeptin-10?

No. A chromatogram shows the share of signal in one peak and says nothing about what that peak is, so it needs a mass result from the same lot beside it.

### What should lot documentation for this bottle show?

A lot number matching the bottle label, the compound and chemical form, an HPLC trace with its method, observed and expected mass, the test date and the laboratory. Documentation can be requested through the contact page.

### What does the Research Use Only designation rule out for this bottle?

It marks the bottle as a laboratory reagent for research and analysis, not for use in people or animals.

### Does Veracue provide usage guidance for Kisspeptin Spray?

No. Veracue provides no dosing, administration or usage guidance of any kind for this research item.

More from Veracue Labs: https://veracuelabs.com/llms.txt