# CJC-1295 W/DAC

> Research use only. Not for human or veterinary use. Supplied by Veracue Labs.

- Page: https://veracuelabs.com/product/cjc-1295-w-dac
- Category: Growth Hormone Secretagogue
- Sizes and prices in USD: 5 mg at $76.99
- Certificate of analysis: none posted on the page. Request one for a specific lot at https://veracuelabs.com/contact-us.
- Prices are a snapshot from 2026-10-17. The product page shows the current price.

## Overview

CJC-1295 W/DAC is a 30-residue synthetic peptide: the GHRH(1-29) analog YADAIFTQSYRKVLAQLSARKLLQDILSR, with D-alanine at position 2, extended by a C-terminal lysinamide whose side chain carries a maleimidopropionyl albumin-binding group known as the Drug Affinity Complex. Its formula is C165H269N47O46, average mass about 3647.2 g/mol, CAS 446262-90-4. That added group makes it roughly 279 Da heavier than the unmodified 29-residue peptide at 3367.9 g/mol, so a mass reading separates the two.

## Product Details

### About CJC-1295 W/DAC

CJC-1295 W/DAC is a synthetic peptide of thirty residues. Its backbone is a modified version of the first 29 amino acids of growth hormone-releasing hormone, GHRH(1-29), and the thirtieth residue, a C-terminal lysinamide, carries the part that gives the compound its name: a 3-maleimidopropionyl group sold under the trademark Drug Affinity Complex, or DAC. The maleimide end of that group is thiol-reactive, and the group was designed to bind a free thiol on albumin.

The same molecule is written CJC-1295 DAC, CJC-1295 with DAC and DAC:GRF. Across the supplier market the bare name CJC-1295 is also attached to the version that lacks the DAC group, so the extra group, and the mass it adds, is the quickest way to tell which compound a label really describes.

### Identity Card

Product name: CJC-1295 W/DAC (also CJC-1295 DAC, CJC-1295 with DAC, DAC:GRF)
Molecule type: Synthetic peptide, 30 residues, with a lysine-linked maleimidopropionyl group
Residues 1 to 29: Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg (YADAIFTQSYRKVLAQLSARKLLQDILSR)
Residue 30: Lysine, C-terminal amide, 3-maleimidopropionyl on the side-chain amine
Molecular formula (free peptide): C165H269N47O46
Molecular weight (average): About 3647.2 g/mol
CAS Registry Number: 446262-90-4
UNII: 62RC32V9N7
PubChem CID: 91971820
Size offered: 5 mg vial
Research designation: Research Use Only

Formula, mass and registry numbers describe the free peptide as a reference and are not a Veracue lot result. Chemical form, purity, lot number and storage details are given on each lot’s own documentation, which the contact page explains how to request.

### Easily Mistaken For

- The unmodified 29-residue peptide, Modified GRF(1-29), sometimes sold as CJC-1295 without DAC. It has no maleimidopropionyl group and a mass near 3367.9 g/mol.
- Sermorelin, the native GHRH(1-29) amide, which differs from CJC-1295 W/DAC at four positions and has its own CAS number.
- Tesamorelin or ipamorelin, which are separate molecules built on different sequences.
- A consumer, dietary or veterinary product. Veracue supplies CJC-1295 W/DAC for laboratory research only.

## Research Focus & Mechanism Overview

### Structure, Position by Position

Start from native GHRH(1-29), the chain used in sermorelin. Four positions differ in CJC-1295 W/DAC and a thirtieth residue is added. Each change is a place where a look-alike material can go wrong, which is why they are worth knowing.

Position: Native GHRH(1-29): CJC-1295 W/DAC: Relevance to identity checks

2: L-Ala: D-Ala: Same mass as the L form, so mass alone cannot confirm it
8: Asn: Gln: One extra CH2 group, about 14 Da heavier
15: Gly: Ala: One extra CH2 group, about 14 Da heavier
27: Met: Leu: About 18 Da lighter, and it removes the only sulfur atom
30: Not present: Lys with a maleimidopropionyl side chain: Adds about 279.3 Da to the 29-residue core

Added up, the four substitutions leave the 29-residue core at C152H252N44O42, about 3367.9 g/mol. The lysinamide and maleimidopropionyl extension then takes the molecule to C165H269N47O46, about 3647.2 g/mol. The two formulas differ by C13H17N3O4.

### What does the residue makeup say?

Counting the sequence gives five leucines, four alanines (one of them D-alanine), three each of arginine, glutamine and serine, and one to three of the remaining residues. There is no cysteine, so the peptide has no thiol of its own for the maleimide to react with, and no methionine or tryptophan, the residues analysts most often watch for oxidation. Three arginines, two free lysines and the N-terminal amine outweigh the only two acidic residues, both aspartates, so the chain is net positive at neutral pH.

### The DAC Group

DAC stands for Drug Affinity Complex. Chemically it is a 3-maleimidopropionyl group attached to the side-chain amine of the C-terminal lysine. A maleimide reacts readily with a free thiol to form a covalent thioether bond, and in this design the intended partner is a free thiol on albumin. For an analyst the practical point is simpler: the group is a defined, reactive part of the molecule, and its presence, absence or alteration shows up directly in the measured mass.

### Mass Check Against Look-alikes

Feature: CJC-1295 W/DAC: Unmodified 29-residue core: Sermorelin

Residues: 30: 29: 29
Molecular formula: C165H269N47O46: C152H252N44O42: C149H246N44O42S
Average mass: About 3647.2 g/mol: About 3367.9 g/mol: About 3357.9 g/mol
Position 2: D-Ala: D-Ala: L-Ala
Maleimidopropionyl group: Present: Absent: Absent
CAS Registry Number: 446262-90-4: Separate entries that vary between supplier catalogs: 86168-78-7

A reading near 3647 fits the DAC form. A reading near 3368 under a W/DAC label points to the unmodified core instead, a gap of roughly 279 Da that an ordinary mass spectrometer resolves with ease.

### Receptor Context and Reading Literature

CJC-1295 is studied as a ligand for the GHRH receptor, a G protein-coupled receptor on pituitary somatotroph cells that signals mainly through adenylyl cyclase and cyclic AMP. Because the bare name covers more than one molecule, a paper or a supplier sheet should be matched to this compound by sequence, formula and CAS number, and findings reported for the unmodified form should not be carried across to the DAC form. Reports also do not always say whether a free peptide or a salt was used, and a salt changes the formula weight. Veracue offers molecular reference information here and provides no dosing, administration or usage guidance of any kind.

## Quality & Purity Standards

### Documentation Worth Asking For

A certificate describes one lot, so the first check is that its lot number matches the vial. For a peptide that carries a reactive modification, a few items deserve extra attention.

Item on the certificate: Why it matters for this peptide

Observed mass: Should sit near 3647.2 g/mol for the free peptide. A value near 3367.9 indicates the unmodified core.
Chemical form: Free peptide, acetate or another salt. The form changes the formula weight used to compare masses.
HPLC trace and area percent: Shows chromatographic purity only, not which molecule the main peak is.
Sequence evidence: Tandem MS fragments support residue order but do not separate D-Ala from L-Ala by themselves.
Chirality check: Chiral amino acid analysis, or comparison with a reference standard, is the way to support the D-alanine at position 2.
Net peptide content: Separates peptide from counterions and water, a different figure from HPLC purity.
Test date and laboratory: Ties the result to a named laboratory and a date.

Results and storage details are reported on each lot’s own documentation, and the certificate page explains how to request it.

### Reading the Mass Spectrum

At about 3647 g/mol the peptide is unlikely to appear as one peak at its neutral mass. Electrospray spectra of a peptide this size, with this many basic sites, usually contain several multiply charged ions. On an average-mass basis the 5+ ion falls near m/z 730.4 and the 6+ ion near m/z 608.9, and software converts such ions back to a neutral mass for comparison with the reference value.

Because a maleimide can react with a thiol or open its ring by taking up water, a spectrum may also contain minor species shifted by the mass of an added thiol or by about 18 Da. Those are worth noticing, and they are one more reason to read the whole spectrum instead of a single number.

### Questions Researchers Raise When Verifying a Lot

### Does a high HPLC percentage prove the vial holds CJC-1295 W/DAC?

No. A sharp main peak shows that most of the detected material behaves alike, not that it is the DAC peptide. Look for a mass result from the same lot, reported as observed against expected mass, alongside the purity figure.

### The certificate lists a mass near 3368. What does that suggest?

That figure matches the 29-residue core without the lysine-linked maleimidopropionyl group, not CJC-1295 W/DAC. A label that says DAC next to that mass is worth raising with the supplier before any work begins.

### Can mass spectrometry confirm the D-alanine at position 2?

Not on its own. D-alanine and L-alanine have identical mass, so the spectrum cannot distinguish them. Chiral amino acid analysis or a reference comparison can supply that evidence.

### Need lot documentation for CJC-1295 W/DAC?

Ask the Veracue team about the documentation available for a given lot, or browse the certificate library.

- Request lot documentation
- View certificates
- Browse the research catalog

## Compliance Notice

### Research Use Only Notice

CJC-1295 W/DAC is supplied for laboratory research and analytical characterization only. It is not intended for human or veterinary use, or for ingestion, injection or any form of administration, and it is not a drug, dietary supplement, cosmetic or food. Veracue provides no dosing, administration or usage guidance of any kind and makes no pharmacokinetic claims for this material. Purchasers must be qualified researchers or institutions and must use the material in line with all applicable laws. See the Medical Disclaimer and the Terms and Conditions for sitewide policies.

## Questions and answers

### What is CJC-1295 W/DAC?

CJC-1295 W/DAC is a 30-residue synthetic peptide: a modified GHRH(1-29) chain extended by a C-terminal lysinamide that carries a 3-maleimidopropionyl group. Veracue supplies it for laboratory research only.

### What does DAC stand for in CJC-1295?

Drug Affinity Complex. It is a 3-maleimidopropionyl group on the side-chain amine of the C-terminal lysine, a thiol-reactive group designed to bind a free thiol on albumin.

### What is the amino acid sequence of CJC-1295 W/DAC?

Residues 1 to 29 are Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg (YADAIFTQSYRKVLAQLSARKLLQDILSR). Residue 30 is the C-terminal lysinamide carrying the maleimidopropionyl group.

### What are the molecular formula and molecular weight?

The free peptide is C165H269N47O46 with an average molecular weight of about 3647.2 g/mol. A salt form has a higher formula weight.

### Which CAS number applies to CJC-1295 W/DAC?

CAS 446262-90-4, with UNII 62RC32V9N7 and PubChem CID 91971820. Sermorelin has a different CAS number, 86168-78-7, and a different sequence.

### How much heavier is CJC-1295 W/DAC than the unmodified 29-residue peptide?

About 279.3 g/mol, which is 3647.2 against 3367.9. The gap is the added lysinamide and maleimidopropionyl group, C13H17N3O4.

### Is CJC-1295 W/DAC the same as Mod GRF 1-29?

No. Modified GRF(1-29) is the 29-residue core without the lysine-linked DAC group, so its formula, mass and CAS entry differ. The two should be verified separately.

### Does the sequence contain residues prone to oxidation?

It has no methionine, cysteine or tryptophan. The methionine found at position 27 of the native sequence is replaced by leucine, so the formula contains no sulfur.

### Which receptor is CJC-1295 studied at?

The GHRH receptor, a G protein-coupled receptor on pituitary somatotroph cells that signals mainly through adenylyl cyclase and cyclic AMP. Ghrelin-receptor peptides such as ipamorelin act through a different receptor.

### Does Veracue publish a half-life for CJC-1295 W/DAC?

No. Half-life is measured in living systems, and Veracue makes no pharmacokinetic claims for this material. The listing documents chemical identity only.

### What size does the CJC-1295 W/DAC vial come in?

One size is offered, a 5 mg vial, supplied for laboratory research use only.

### What belongs on a certificate of analysis for this peptide?

A lot number matching the vial, the chemical form, an HPLC result with chromatogram, a mass result showing observed against expected mass near 3647.2, a chirality or reference check for the D-alanine, the test date and the laboratory.

### What does Research Use Only mean?

It means the material is supplied only for laboratory research and analysis, not for human or veterinary use, ingestion, injection or any form of administration.

### Does Veracue provide usage instructions for CJC-1295 W/DAC?

No. CJC-1295 W/DAC is offered for laboratory research use only, and Veracue provides no dosing, administration or usage guidance of any kind.

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