# CJC-1295 W/DAC Spray

> Research use only. Not for human or veterinary use. Supplied by Veracue Labs.

- Page: https://veracuelabs.com/product/cjc-1295-w-dac-spray
- Category: Nasal Sprays
- Sizes and prices in USD: 5 mg at $93.49
- Certificate of analysis: none posted on the page. Request one for a specific lot at https://veracuelabs.com/contact-us.
- Prices are a snapshot from 2026-10-17. The product page shows the current price.

## Overview

CJC-1295 W/DAC Spray is spray-dispensed CJC-1295 W/DAC, a 30-residue GHRH(1-29) analog: the chain YADAIFTQSYRKVLAQLSARKLLQDILSR, with D-alanine at position 2, followed by a C-terminal lysinamide that carries a 3-maleimidopropionyl group on its side chain. Reference values are formula C165H269N47O46, average mass about 3647.2 g/mol, CAS 446262-90-4 and PubChem CID 91971820. It comes as a 5 mg bottle with 45 sprays per bottle. Veracue supplies it strictly for laboratory research use only.

## Product Details

### Product Snapshot

Product name: CJC-1295 W/DAC Spray (peptide also written CJC-1295 DAC or DAC:GRF)
Format: Spray-dispensed bottle
Strength: 5 mg
Sprays per bottle: 45 sprays per bottle
Peptide length: 30 residues: a 29-residue GHRH(1-29) analog plus a C-terminal lysinamide
Core sequence: YADAIFTQSYRKVLAQLSARKLLQDILSR, with D-alanine at position 2
Modification: 3-maleimidopropionyl group (the Drug Affinity Complex) on the side chain of the C-terminal lysine
Molecular formula (free peptide): C165H269N47O46
Molecular weight (average): About 3647.2 g/mol
CAS Registry Number: 446262-90-4
UNII: 62RC32V9N7
PubChem CID: 91971820
Research designation: Research Use Only

### The Compound in the Bottle

The bottle holds CJC-1295 W/DAC, an analog of growth hormone-releasing hormone assembled from the first 29 amino acids of the native sequence with four substitutions, then extended by a single lysine that carries a maleimide-based group called the Drug Affinity Complex. The extra lysine is why the chain count reads 30 rather than 29.

Bottles come in one 5 mg strength with 45 sprays per bottle. Concentration, fill volume, chemical form and lot results are reported on each lot’s own documentation, which can be requested through the contact page.

### Names and Look-alikes

- CJC-1295 DAC, CJC-1295 with DAC and DAC:GRF are all names for this peptide.
- CJC-1295 without DAC, also called Modified GRF(1-29), is a 29-residue peptide that lacks the maleimidopropionyl lysine. Its formula is C152H252N44O42.
- Sermorelin and tesamorelin are separate GHRH-related peptides, each with its own sequence and CAS number.
- Not a consumer, dietary, cosmetic or veterinary product.

## Research Focus & Mechanism Overview

### Anatomy of the Peptide

Three layers make up the molecule. The first is the native GHRH(1-29) chain. The second is a set of four changes to it: D-alanine in place of L-alanine at position 2, glutamine for asparagine at 8, alanine for glycine at 15 and leucine for methionine at 27. The third is a thirtieth residue, lysine, joined at the C-terminus as an amide and bearing a 3-maleimidopropionyl group on its side-chain amine.

The four substitutions were introduced in the published design of this analog to improve resistance to enzymatic breakdown while keeping receptor binding. The added group, the Drug Affinity Complex, is a maleimide intended to bond covalently with a free thiol on albumin.

### Residue Inventory

Residue: Count: Positions

Leucine: 5: 14, 17, 22, 23, 27
Alanine: 4: 2 (D-form), 4, 15, 19
Arginine: 3: 11, 20, 29
Glutamine: 3: 8, 16, 24
Lysine: 3: 12, 21, 30 (side chain carries the DAC group)
Serine: 3: 9, 18, 28
Tyrosine: 2: 1, 10
Aspartic acid: 2: 3, 25
Isoleucine: 2: 5, 26
Phenylalanine: 1: 6
Threonine: 1: 7
Valine: 1: 13

No cysteine, methionine or tryptophan appears anywhere in the chain. Lysine 30 is counted above, but its side-chain amine is acylated, so the positive charge at neutral pH comes from lysines 12 and 21, the three arginines and the N-terminal amine, set against two aspartates.

### How It Compares With Related GHRH Peptides

Feature: CJC-1295 W/DAC: CJC-1295 without DAC: Sermorelin: Tesamorelin

Chain length: 30 residues: 29 residues: 29 residues: 44 residues
Molecular formula: C165H269N47O46: C152H252N44O42: C149H246N44O42S: C221H366N72O67S
Average mass: About 3647.2 g/mol: About 3367.9 g/mol: About 3357.9 g/mol: About 5135.9 g/mol
Residue 2: D-Ala: D-Ala: L-Ala: L-Ala
Added group: Maleimidopropionyl on a C-terminal lysine: None: None: N-terminal trans-3-hexenoyl
CAS Registry Number: 446262-90-4: Separate entries that vary between supplier catalogs: 86168-78-7: 218949-48-5 (free base)

The table covers structure and identifiers only and ranks nothing.

### Receptor Background

CJC-1295 is studied as a GHRH-receptor ligand. That receptor is a G protein-coupled receptor found on pituitary somatotroph cells, and it signals mainly through adenylyl cyclase and cyclic AMP. Naming the exact molecule by sequence or CAS number in methods sections keeps results attributable to the right compound.

## Quality & Purity Standards

### Verifying a Bottle of CJC-1295 W/DAC Spray

Start by matching the lot number on the bottle to the certificate, then read four things in order.

- Expected mass: about 3647.2 g/mol for the free peptide, adjusted for the chemical form the certificate states.
- Purity: an HPLC area percentage with the chromatogram attached.
- Identity method: mass spectrometry with observed and expected mass, plus fragment evidence for the sequence if the laboratory ran it.
- Bottle-level figures: concentration and fill volume for this lot, stated on the lot’s own documentation rather than assumed from the listing.

The certificate page explains how to request lot documentation.

### Charge States to Expect in an Electrospray Spectrum

A 3647 g/mol peptide with this many basic sites is expected to carry several charges in electrospray, so the spectrum shows a ladder of ions rather than one peak at the neutral mass.

Charge state: Approximate m/z (average mass)

3+: 1216.7
4+: 912.8
5+: 730.4
6+: 608.9

These values come from the 3647.2 reference mass plus one proton per charge, and instrument-reported monoisotopic values usually read lower. Peaks that fall far from this ladder suggest a different molecule, such as the 3367.9 g/mol unmodified core.

### What the Reactive Group Means for Identity Data

A maleimide reacts with thiols and can also open its ring by taking up water, which adds about 18 Da. Either event leaves the rest of the peptide intact but shifts the measured mass. A clean spectrum at the expected value therefore supports a molecule with its maleimide intact, while shifted companion peaks are a reasonable question to put to the laboratory.

### Frequently Raised Verification Points

### Why does the D-alanine at position 2 need its own evidence?

D-alanine and L-alanine have identical mass, so a mass spectrum cannot tell them apart. Chiral amino acid analysis or a comparison with a reference standard is what supports the D form.

### Why must the chemical form appear on the certificate?

A free peptide and its salt forms share one sequence but not one formula weight. Without the stated form, a mass-based calculation can carry a silent error.

### Request Lot Documentation

Contact the Veracue team about the documentation available for a specific lot.

- Contact the Veracue team
- Certificate library
- Research catalog

## Compliance Notice

### Research Use Only Notice

CJC-1295 W/DAC Spray is sold to qualified researchers and institutions for laboratory research and analytical work. It is not for human or veterinary use, it must not be ingested, injected or administered in any form, and it is not a drug, supplement, cosmetic or food. The listing carries molecular and analytical reference information only, and Veracue provides no dosing, administration or usage guidance of any kind. Buyers are responsible for handling the material in line with applicable law and their institution’s policies. Sitewide policies are set out in the Medical Disclaimer and the Terms and Conditions.

## Questions and answers

### What compound is in CJC-1295 W/DAC Spray?

CJC-1295 W/DAC, a 30-residue peptide made of a modified GHRH(1-29) chain plus a C-terminal lysinamide that carries a 3-maleimidopropionyl group. Veracue supplies it for laboratory research only.

### What are the bottle size and spray count?

Each bottle is the 5 mg strength and holds 45 sprays.

### Why is the chain 30 residues when the core is called GHRH(1-29)?

The core has 29 residues. A thirtieth residue, a C-terminal lysine amide, is added to carry the maleimidopropionyl group.

### How is the DAC group attached?

Through the side-chain amine of lysine 30, as a 3-maleimidopropionyl amide. The maleimide end is thiol-reactive.

### What formula and mass should a certificate reflect?

C165H269N47O46 and an average mass of about 3647.2 g/mol for the free peptide. A salt form has a higher formula weight, so the stated form matters.

### What do CAS 446262-90-4, UNII 62RC32V9N7 and CID 91971820 identify?

All three are registry identifiers for CJC-1295 with the DAC group, the compound in this bottle. They are not the identifiers of the unmodified 29-residue peptide.

### What does a certificate mass near 3368 mean?

It matches the 29-residue core without the DAC group, C152H252N44O42 at about 3367.9 g/mol, rather than CJC-1295 W/DAC at about 3647.2.

### Is CJC-1295 W/DAC the same as sermorelin or tesamorelin?

No. Sermorelin is the native 29-residue GHRH amide at about 3357.9 g/mol, and tesamorelin is a 44-residue analog at about 5135.9 g/mol. Each has its own sequence and CAS number.

### What ions should an electrospray spectrum of this peptide show?

A ladder of multiply charged ions. On an average-mass basis the 4+ ion falls near m/z 912.8, the 5+ near 730.4 and the 6+ near 608.9.

### Which amino acids are absent from the sequence?

Cysteine, methionine and tryptophan do not appear, and neither do histidine, proline, glycine, glutamic acid or asparagine. Methionine 27 and asparagine 8 of the native chain are replaced by leucine and glutamine.

### Does the maleimide group react with thiol-containing reagents?

Maleimides are thiol-reactive in general, so a thiol-containing reagent in an assay mixture is a chemical point to weigh when interpreting results or mass data.

### How is a CJC-1295 W/DAC lot characterized?

Mainly by reverse-phase HPLC for purity and mass spectrometry for identity, with tandem MS for sequence evidence and chiral amino acid analysis for the D-alanine. HPLC alone does not confirm identity.

### What does Research Use Only mean for this product?

The material is supplied only for laboratory research and analysis, not for human or veterinary use, ingestion, injection or any form of administration.

### Does Veracue provide usage instructions for CJC-1295 W/DAC Spray?

No. CJC-1295 W/DAC Spray is offered for laboratory research use only, and Veracue provides no dosing, administration or usage guidance of any kind.

More from Veracue Labs: https://veracuelabs.com/llms.txt