# 5-Amino-1MQ > Research use only. Not for human or veterinary use. Supplied by Veracue Labs. - Page: https://veracuelabs.com/product/5-amino-1mq - Category: GLP-1 & Metabolic - Sizes and prices in USD: 50 mg at $76.99 - Certificate of analysis: none posted on the page. Request one for a specific lot at https://veracuelabs.com/contact-us. - Prices are a snapshot from 2026-10-17. The product page shows the current price. ## Overview 5-Amino-1MQ is a quinoline-based organic cation, formally 5-amino-1-methylquinolinium, with no amino acid sequence, so it is not a peptide. The cation has the formula C10H11N2+ and an average mass near 159.21 g/mol (PubChem CID 950107); its iodide salt, C10H11IN2, weighs 286.11 g/mol and is registered as CAS 42464-96-0 (PubChem CID 66522933), which is why two molar masses circulate for one name. Researchers use it to probe the enzyme NNMT. ## Product Details ### About 5-Amino-1MQ Behind the abbreviation 5-Amino-1MQ is a compact organic ion built on quinoline, a benzene ring fused to a pyridine ring. A methyl group sits on the ring nitrogen, which gives that nitrogen a permanent positive charge, and an amino group is attached at position 5 on the benzene-derived half of the ring system. The result is a cation with the formula C10H11N2+, not a neutral molecule. There is no chain of residues here, no peptide bond and nothing to sequence, so it is not a peptide, even though catalogs and search results often shelve it beside peptides. Chemically it is a small-molecule enzyme probe, and the checks that matter for it are structural and mass-based rather than sequence-based. Veracue supplies it for research use only. ### Reading the Name Each part of the name carries structure. "1MQ" stands for 1-methylquinolinium, the parent ring system, and "5-Amino" places the amine on carbon 5. Related members of the methylquinolinium family carry amino or methyl groups at other positions, so shorthand such as 5A1MQ or 5 amino 1MQ should be checked against the full systematic name before results from two sources are compared. ### Specifications Product name: 5-Amino-1MQ Systematic name: 5-Amino-1-methylquinolinium Other spellings: 5A1MQ, 5 amino 1MQ Compound class: Small organic cation, not a peptide Cation formula: C10H11N2+ Cation average mass: About 159.21 g/mol Cation PubChem CID: 950107 Iodide salt formula: C10H11IN2 Iodide salt average mass: 286.11 g/mol Iodide salt CAS Registry Number: 42464-96-0 Iodide salt PubChem CID: 66522933 Supplied size: 50 mg vial Research designation: Research Use Only These are database reference values for the cation and for its iodide salt, not measurements from a specific Veracue lot. Which form a given vial contains, together with its purity and lot number, is stated on that lot’s own documentation, and the team can be reached on the contact page. ### Common Mix-Ups - Not a peptide: there is no residue chain to sequence, so peptide-style terms such as truncated sequence or multiply charged ions do not apply. - Not 1-methylnicotinamide, the product of the NNMT reaction. That is a different and smaller cation, C7H9N2O+, about 137.16 g/mol. - Not nicotinamide or any other NAD+ precursor. Those are pathway substrates, whereas 5-Amino-1MQ is studied as something that acts on an enzyme. - Not supplied for human or veterinary use, and not meant as a household, dietary or cosmetic item. ## Research Focus & Mechanism Overview ### The Enzyme at the Center: NNMT NNMT, short for nicotinamide N-methyltransferase (EC 2.1.1.1), works in the cell’s cytosol. Its reaction is a single methyl transfer: the donor is S-adenosylmethionine (SAM), the cell’s main source of methyl groups, and the acceptor is nicotinamide. The outcome is 1-methylnicotinamide (1-MNA) plus S-adenosylhomocysteine (SAH). Molecule: Role in the NNMT reaction: Why it matters to the wider pathway Nicotinamide: Methyl acceptor (substrate): Also the starting material recycled in NAD+ salvage SAM: Methyl donor (co-substrate): Also supplies methyl groups to many other methylation reactions 1-MNA: Product: Commonly measured as a readout of NNMT activity SAH: Co-product: Left behind when SAM gives up its methyl group Because nicotinamide and SAM are both drawn on by other pathways, NNMT is treated as a point where NAD+ supply and cellular methylation capacity meet. Nicotinamide that is methylated here becomes 1-MNA instead of being recycled toward NAD+. ### What 5-Amino-1MQ Is Used to Probe 5-Amino-1MQ comes from a series of methylquinolinium compounds developed as NNMT inhibitors. Characterization of the series reported that analogues carrying primary amine groups crossed membranes readily, and that they did not inhibit the related SAM-dependent methyltransferases or the NAD+ salvage enzymes that were tested. That selectivity is why the compound is used to ask a narrow question: what changes in an enzyme assay or a cell when the NNMT step is blocked and its neighbors are left alone. In cultured cells, the readouts that have been followed are the NNMT product 1-MNA, intracellular NAD+ and SAM. Lower 1-MNA together with higher NAD+ and SAM is the pattern reported for inhibitors of this series in that work, and it is the mechanistic reason for the research interest. ### Scope of the Published Work Published reports on this compound and its series sit in enzyme assays, cultured cells and rodent models. Each describes one system, one set of conditions and one readout, so a result is best read as a statement about that system. Proposed explanations, such as NNMT inhibition changing how much nicotinamide and SAM a cell has to work with, remain open questions, not established facts. Veracue offers molecular reference information only, and provides no dosing, administration or usage guidance of any kind. ### Matching a Report to the Right Molecule Before comparing a paper with your own work, confirm the following: - The amino group is at position 5 and the methyl group is on the ring nitrogen, since neighbors in the series differ by position. - The enzyme preparation, cell type or species, and the exact readout used. - Whether 5-Amino-1MQ itself, or another member of the series, was the compound tested. - Whether quantities are quoted for the bare cation or for a named salt, because the same mass holds different numbers of moles in each. On a mass basis the cation makes up only about 56 percent of the iodide salt (159.21 of 286.11), so a figure quoted for one form cannot be carried over to the other without correcting for the counter-ion. ## Quality & Purity Standards ### Verifying a Small Cation, Not a Peptide Sequence Documentation for a peptide leans on sequence confirmation and on multiply charged ions in the mass spectrum. None of that applies to 5-Amino-1MQ. For a small cation the verification questions are narrower: how dominant the main chromatographic peak is, whether the measured mass matches the cation, and which counter-ion accompanies it in the weighed solid. Check: What it establishes: What it leaves open Reverse-phase HPLC: Share of the detected signal that sits in the main peak, under stated conditions: Identity, and anything the detector does not register, such as counter-ion or water Positive-mode ESI or LC-MS: That the cation is present, at about m/z 159.09: Which positional isomer it is, since isomers share one mass; also the counter-ion Stated chemical form: Whether the lot is the bare cation or a named salt, and so which formula weight applies: Nothing by itself unless the method behind the statement is named Lot number, laboratory and test date: That the results trace to the vial in hand: Results for any other lot ### Which Mass Belongs to Which Species Species: Formula: Average mass: How it shows up 5-Amino-1MQ cation: C10H11N2+: About 159.21 g/mol: One positive ion near m/z 159.09 (monoisotopic) in positive mode Iodide salt, as weighed: C10H11IN2: 286.11 g/mol: The same cation at the same m/z; the iodide anion registers only near m/z 126.9 in negative mode 1-Methylnicotinamide (NNMT product): C7H9N2O+: About 137.16 g/mol: A separate cation at a clearly different mass A salt reaches the mass spectrometer as its separate ions rather than as one intact formula unit, which is why a spectrum of the iodide salt still shows the cation near m/z 159 and not at 286. ### Chromatographic Purity Versus Cation Content An HPLC purity figure describes the organic signal the method detects. It does not account for the counter-ion, water or other components that add to the weighed mass of a salt, so a high purity percentage does not say how much cation a given weight of solid contains. Read it beside an identity result, the method conditions and the stated form. ### What a 5-Amino-1MQ Certificate Should Show - The compound name and its exact form: the bare cation or a named salt such as the iodide - A lot number that matches the vial in hand - An HPLC result with its method conditions and chromatogram - A mass result stated as observed against expected m/z for the form named - The testing laboratory and the test date A certificate describes one lot, so check the lot number before using any figure and confirm the form before choosing a formula weight. Purity, form and storage conditions for a vial are reported on its own documentation, and it can be requested through the certificate page. ### Verification Questions ### Can mass spectrometry alone confirm 5-Amino-1MQ? It confirms that a cation of the right mass is present, but positional isomers such as other amino-1-methylquinolinium ions share that mass. Treat the mass result as one piece of identity evidence and look for a second, structure-sensitive one, such as a retention-time match to a reference standard. ### Why must the chemical form be written on the certificate? The cation and its iodide salt differ by about 127 g/mol, the mass of the iodide (159.21 against 286.11). A calculation built on the wrong one is off by a factor of about 1.8, and a stated form removes the guesswork. ### What belongs in a record for each lot? Keep the lot-specific certificate, the stated form, the receipt date and the experiments that used the material. A record like that makes lot-to-lot differences traceable when a result looks unexpected. ### Questions About a 5-Amino-1MQ Lot? Ask the Veracue team which documentation is available for a specific lot, or look through the published certificates. - Ask about a lot - Certificates archive - Research catalog ## Compliance Notice ### Research Use Only 5-Amino-1MQ is supplied for laboratory research and analytical work only. It is not intended for human or veterinary use, or for ingestion, injection or any other form of administration, and it is not a drug, dietary supplement, cosmetic or food. Veracue provides no dosing, administration or usage guidance of any kind. Buyers must be qualified researchers or institutions and are responsible for lawful handling. Sitewide terms are set out in the Medical Disclaimer and the Terms and Conditions. The research context given for this product is limited to chemistry and enzyme-level biology. It makes no claim about any effect in people or animals. ## Questions and answers ### What does the name 5-Amino-1MQ stand for? It abbreviates 5-amino-1-methylquinolinium: a quinolinium ring system with a methyl group on the ring nitrogen (the 1MQ part) and an amino group at position 5. The spellings 5A1MQ and 5 amino 1MQ refer to the same ion. ### Does 5-Amino-1MQ have an amino acid sequence? No. It is a single fused-ring organic cation with no residues and no peptide bonds, so the sequence-based checks used for peptides do not apply to it. ### What are the formula and mass of the 5-Amino-1MQ cation? The cation is C10H11N2+ with an average mass of about 159.21 g/mol, recorded in PubChem as CID 950107. ### Which CAS number goes with 5-Amino-1MQ? CAS 42464-96-0 is the registry number of the iodide salt, C10H11IN2, 286.11 g/mol, PubChem CID 66522933. The bare cation is catalogued separately under PubChem CID 950107. ### Why is 159.21 g/mol quoted in some places and 286.11 g/mol in others? The first figure is the cation alone and the second is its iodide salt, which adds the roughly 127 g/mol iodide counter-ion. The form a particular lot contains decides which one belongs in a calculation. ### Which enzyme is 5-Amino-1MQ studied against? NNMT, or nicotinamide N-methyltransferase. In the cytosol it hands a methyl group from SAM to nicotinamide, forming 1-methylnicotinamide. ### What does NNMT produce when it acts on nicotinamide? 1-methylnicotinamide (1-MNA) and S-adenosylhomocysteine (SAH). 1-MNA is the product most often measured as a readout of the reaction. ### Which readouts are followed when NNMT is blocked in cells? Reports track intracellular 1-MNA, NAD+ and SAM. In the work on this compound series, lower 1-MNA came with higher NAD+ and SAM in cultured cells. ### How does 5-Amino-1MQ differ from nicotinamide or an NAD+ precursor? Nicotinamide and NAD+ precursors are substrates that feed the NAD+ pathway. 5-Amino-1MQ is a quinolinium ion used to block the enzyme that methylates nicotinamide, so it enters the picture at a different point in the pathway. ### Can mass spectrometry alone confirm the compound? It shows that a cation of the right mass is present, near m/z 159.09 in positive mode, but positional isomers share that mass. A second line of evidence, such as a retention-time match to a reference standard, strengthens identity. ### Does a purity percentage tell me how much cation is in the vial? No. HPLC purity describes the detected organic signal and ignores the counter-ion and water that add to the weighed mass of a salt. ### What should a 5-Amino-1MQ certificate list? The compound and its exact form, a lot number matching the vial, an HPLC result with its conditions, a mass result of observed against expected m/z, and the laboratory and test date. ### What size of 5-Amino-1MQ does Veracue offer? A 50 mg vial, supplied for laboratory research use only. ### What does the Research Use Only label cover for this compound? It limits the material to laboratory research and analysis, with no human or veterinary use and no form of administration. ### Will Veracue supply directions for using 5-Amino-1MQ? No. The compound is sold for laboratory research only, and Veracue provides no dosing, administration or usage guidance of any kind. More from Veracue Labs: https://veracuelabs.com/llms.txt